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The treatment of all the animals was in strict accordance with the requirements of animal experiments at Shandong University (Jinan, Shandong, China), which were approved by the Ethics Committee of the School of Life Science, Shandong University

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Tirzepatide Reconstitution Math Tirzepatide - dose per draw at common vial sizes Vial Size 5 mg BAC Water 1.0 mL Concentration 5 mg/mL 2.5 mg 0.50 mL (50 units) 5 mg 1.00 mL (100 units) 10 mg N/A 15 mg N/A Vial Size 10 mg BAC Water 2.0 mL Concentration 5 mg/mL 2.5 mg 0.50 mL (50 units) 5 mg 1.00 mL (100 units) 10 mg 2.00 mL (200 units*) 15 mg 3.00 mL (300 units*) Vial Size 10 mg BAC Water 1.0 mL Concentration 10 mg/mL 2.5 mg 0.25 mL (25 units) 5 mg 0.50 mL (50 units) 10 mg 1.00 mL (100 units) 15 mg 1.50 mL (150 units*) Vial Size 30 mg BAC Water 3.0 mL Concentration 10 mg/mL 2.5 mg 0.25 mL (25 units) 5 mg 0.50 mL (50 units) 10 mg 1.00 mL (100 units) 15 mg 1.50 mL (150 units*) * Volumes above 100 units exceed a standard 1 mL insulin syringe